The preparation of homogentisic acid and of 2:5-dihydroxyphenylethylamine

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The preparation of homogentisic acid and of 2:5-dihydroxyphenylethylamine.

This acid was synthesized soon after its discovery in alcaptonuric urine by Baumann & Fraenkel (1894) from 2:5-dimethoxybenzaldehyde by successive conversion to the alcohol, chloride and nitrile, followed by hydrolysis. The overall yield was very poor, due mainly to side reactions occurring in the conversion of the chloride to the nitrile. Schoepf & Winterhalder (1940), who studied systematical...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1948

ISSN: 0306-3283

DOI: 10.1042/bj0430606